Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. Although the control of Gli transcription factors by SuFu is critical in Hh signalling, our understanding of the mechanism re...

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Publicado no:Nat Commun
Main Authors: Infante, Paola, Faedda, Roberta, Bernardi, Flavia, Bufalieri, Francesca, Lospinoso Severini, Ludovica, Alfonsi, Romina, Mazzà, Daniela, Siler, Mariangela, Coni, Sonia, Po, Agnese, Petroni, Marialaura, Ferretti, Elisabetta, Mori, Mattia, De Smaele, Enrico, Canettieri, Gianluca, Capalbo, Carlo, Maroder, Marella, Screpanti, Isabella, Kool, Marcel, Pfister, Stefan M., Guardavaccaro, Daniele, Gulino, Alberto, Di Marcotullio, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841288/
https://ncbi.nlm.nih.gov/pubmed/29515120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03339-0
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