Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Enzyme Inhib Med Chem
Hlavní autoři: Calcaterra, Andrea, Iovine, Valentina, Botta, Bruno, Quaglio, Deborah, D’Acquarica, Ilaria, Ciogli, Alessia, Iazzetti, Antonia, Alfonsi, Romina, Lospinoso Severini, Ludovica, Infante, Paola, Di Marcotullio, Lucia, Mori, Mattia, Ghirga, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009951/
https://ncbi.nlm.nih.gov/pubmed/29338454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419221
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky