Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor κB RelA Subunit

Transcription activator proteins typically contain two functional domains: a DNA binding domain (DBD) that binds to DNA with sequence specificity and an activation domain (AD) whose established function is to recruit RNA polymerase. In this report, we show that purified recombinant nuclear factor κB...

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Publicado no:Biochemistry
Main Authors: Mulero, Maria Carmen, Shahabi, Shandy, Ko, Myung Soo, Schiffer, Jamie M., Huang, De-Bin, Wang, Vivien Ya-Fan, Amaro, Rommie E., Huxford, Tom, Ghosh, Gourisankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993198/
https://ncbi.nlm.nih.gov/pubmed/29708732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00158
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