DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated

The nuclear factor κB (NF-κB) transcription factor family regulates genes involved in cell proliferation and inflammation. The promoters of these genes often contain NF-κB-binding sites (κB sites) arranged in tandem. How NF-κB activates transcription through these multiple sites is incompletely unde...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Mulero, Maria Carmen, Huang, De-Bin, Nguyen, H. Thien, Wang, Vivien Ya-Fan, Li, Yidan, Biswas, Tapan, Ghosh, Gourisankar
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704467/
https://ncbi.nlm.nih.gov/pubmed/28935669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.813980
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