NF-κB Regulation: Lessons from Structures

Por Ghosh, Gourisankar, Ya-Fan Wang, Vivien, Huang, De-Bin, Fusco, Amanda
Publicado no Immunol Rev (2012)

The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs

Por Cho, Suhyung, Hoang, Amy, Chakrabarti, Sutapa, Huynh, Nhat, Huang, De-Bin, Ghosh, Gourisankar
Publicado em 2011

X-ray Structure of a NF-κB p50/RelB/DNA Complex Reveals Assembly of Multiple Dimers on Tandem κB Sites

Por Moorthy, Anu K., Huang, De-Bin, Wang, Vivien Ya-Fan, Vu, Don, Ghosh, Gourisankar
Publicado em 2007

Crystal structure of NF-κB (p50)(2) complexed to a high-affinity RNA aptamer

Por Huang, De-Bin, Vu, Don, Cassiday, Laura A., Zimmerman, Jeff M., Maher, L. James, Ghosh, Gourisankar
Publicado em 2003

NF-κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes

Por Fusco, Amanda J, Huang, De-Bin, Miller, Dustyn, Wang, Vivien Ya-Fan, Vu, Don, Ghosh, Gourisankar
Publicado em 2009

Probing Kinase Activation and Substrate Specificity with an Engineered Monomeric IKK2

Por Hauenstein, Arthur V., Rogers, W. Eric, Shaul, Jacob D., Huang, De-Bin, Ghosh, Gourisankar, Huxford, Tom
Publicado em 2014

Role of lysine methylation of NF-κB in differential gene regulation

Por Lu, Tao, Yang, Maojing, Huang, De-Bin, Wei, Han, Ozer, Gulcin H., Ghosh, Gourisankar, Stark, George R.
Publicado em 2013

Euonymus alatus and its monomers alleviate liver fibrosis both in mice and LX2 cells by blocking TβR1-Smad2/3 and TNF-α-NF-κB pathways

Por Wan, Xing, Huang, Han-Cheng, Wang, Xiang-Peng, Hu, Ze-Hua, Liu, Ke-Yun, Huang, De-Bin
Publicado no Am J Transl Res (2019)

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated

Por Mulero, Maria Carmen, Huang, De-Bin, Nguyen, H. Thien, Wang, Vivien Ya-Fan, Li, Yidan, Biswas, Tapan, Ghosh, Gourisankar
Publicado no J Biol Chem (2017)

PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB

Por Wei, Han, Wang, Benlian, Miyagi, Masaru, She, Yun, Gopalan, Banu, Huang, De-Bin, Ghosh, Gourisankar, Stark, George R., Lu, Tao
Publicado em 2013

p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation

Por Tao, Zhihua, Fusco, Amanda, Huang, De-Bin, Gupta, Kushol, Young Kim, Daniel, Ware, Carl F., Van Duyne, Gregory D., Ghosh, Gourisankar
Publicado no Proc Natl Acad Sci U S A (2014)

Structural Basis for the Activation of IKK1/α

Por Polley, Smarajit, Passos, Dario Oliveira, Huang, De-Bin, Mulero, Maria Carmen, Mazumder, Anup, Biswas, Tapan, Verma, Inder M., Lyumkis, Dmitry, Ghosh, Gourisankar
Publicado no Cell Rep (2016)

Protein Cofactors Are Essential for High-Affinity DNA Binding by the Nuclear Factor κB RelA Subunit

Por Mulero, Maria Carmen, Shahabi, Shandy, Ko, Myung Soo, Schiffer, Jamie M., Huang, De-Bin, Wang, Vivien Ya-Fan, Amaro, Rommie E., Huxford, Tom, Ghosh, Gourisankar
Publicado no Biochemistry (2018)

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

Por Polley, Smarajit, Huang, De-Bin, Hauenstein, Arthur V., Fusco, Amanda J., Zhong, Xiangyang, Vu, Don, Schröfelbauer, Bärbel, Kim, Youngchang, Hoffmann, Alexander, Verma, Inder M., Ghosh, Gourisankar, Huxford, Tom
Publicado em 2013

The Specificity of Innate Immune Responses Is Enforced by Repression of Interferon Response Elements by NF-κB p50

Por Cheng, Christine S., Feldman, Kristyn E., Lee, James, Verma, Shilpi, Huang, De-Bin, Huynh, Kim, Chang, Mikyoung, Ponomarenko, Julia V., Sun, Shao-Cong, Benedict, Chris A., Ghosh, Gourisankar, Hoffmann, Alexander
Publicado em 2011