Crystal structure of NF-κB (p50)(2) complexed to a high-affinity RNA aptamer

We have recently identified an RNA aptamer for the transcription factor NF-κB p50 homodimer [(p50)(2)], which exhibits little sequence resemblance to the consensus DNA target for (p50)(2), but binds (p50)(2) with an affinity similar to that of the optimal DNA target. We describe here the 2.45-Å reso...

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Detalhes bibliográficos
Main Authors: Huang, De-Bin, Vu, Don, Cassiday, Laura A., Zimmerman, Jeff M., Maher, L. James, Ghosh, Gourisankar
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC170907/
https://ncbi.nlm.nih.gov/pubmed/12886018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1632011100
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