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hIAPP forms toxic oligomers in plasma
In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic acti...
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| Veröffentlicht in: | Chem Commun (Camb) |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5970100/ https://ncbi.nlm.nih.gov/pubmed/29745410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03097a |
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