The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes

Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is a principal factor contributing to T2D and induces a shift towards a more reducing cellular environment. At the same time, peripheral insuli...

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Udgivet i:Sci Rep
Main Authors: Rodriguez Camargo, Diana C., Tripsianes, Konstantinos, Buday, Katalin, Franko, Andras, Göbl, Christoph, Hartlmüller, Christoph, Sarkar, Riddhiman, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Böddrich, Annett, Erck, Christian, Martens, Henrik, Walch, Axel Karl, Madl, Tobias, Wanker, Erich E., Conrad, Marcus, de Angelis, Martin Hrabě, Reif, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347123/
https://ncbi.nlm.nih.gov/pubmed/28287098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44041
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