Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

The formation of amyloid fibrils by human islet amyloid polypeptide protein (hIAPP) has been implicated in pancreas dysfunction and diabetes. However, efficient treatment options to reduce amyloid fibrils in vivo are still lacking. Therefore, we tested the effect of epigallocatechin gallate (EGCG) o...

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Publicat a:Sci Rep
Autors principals: Franko, Andras, Rodriguez Camargo, Diana C., Böddrich, Annett, Garg, Divita, Rodriguez Camargo, Andres, Rathkolb, Birgit, Janik, Dirk, Aichler, Michaela, Feuchtinger, Annette, Neff, Frauke, Fuchs, Helmut, Wanker, Erich E., Reif, Bernd, Häring, Hans-Ulrich, Peter, Andreas, Hrabě de Angelis, Martin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773570/
https://ncbi.nlm.nih.gov/pubmed/29348618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18807-8
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