Zinc Boosts EGCG’s hIAPP Amyloid Inhibition Both in Solution and Membrane

Amyloid aggregation of human islet amyloid polypeptide (hIAPP) is linked to insulin-producing islet cell death in type II diabetes. Previous studies have shown that Zinc (Zn(II)) and insulin, co-secreted with hIAPP, have an inhibition effect on hIAPP aggregation. Lipid membranes have also been shown...

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Udgivet i:Biochim Biophys Acta Proteins Proteom
Main Authors: Lee, Young-Ho, Lin, Yuxi, Cox, Sarah J., Kinoshita, Misaki, Sahoo, Bikash R., Ivanova, Magdalena, Ramamoorthy, Ayyalusamy
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450719/
https://ncbi.nlm.nih.gov/pubmed/30468883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2018.11.006
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