hIAPP forms toxic oligomers in plasma

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic acti...

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Published in:Chem Commun (Camb)
Main Authors: Rodriguez Camargo, Diana C., Garg, Divita, Buday, Katalin, Franko, Andras, Camargo, Andres Rodriguez, Schmidt, Fabian, Cox, Sarah, Suladze, Saba, Haslbeck, Martin, Mideksa, Yonatan G., Gemmecker, Gerd, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Walch, Axel Karl, de Angelis, Martin Hrabě, Feige, Matthias, Sierra, Cesar A., Conrad, Marcus, Tripsianes, Konstantinos, Ramamoorthy, Ayyalusamy, Reif, Bernd
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970100/
https://ncbi.nlm.nih.gov/pubmed/29745410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03097a
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