hIAPP forms toxic oligomers in plasma

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic acti...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Rodriguez Camargo, Diana C., Garg, Divita, Buday, Katalin, Franko, Andras, Camargo, Andres Rodriguez, Schmidt, Fabian, Cox, Sarah, Suladze, Saba, Haslbeck, Martin, Mideksa, Yonatan G., Gemmecker, Gerd, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Walch, Axel Karl, de Angelis, Martin Hrabě, Feige, Matthias, Sierra, Cesar A., Conrad, Marcus, Tripsianes, Konstantinos, Ramamoorthy, Ayyalusamy, Reif, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970100/
https://ncbi.nlm.nih.gov/pubmed/29745410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03097a
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