hIAPP forms toxic oligomers in plasma

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic acti...

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書誌詳細
出版年:Chem Commun (Camb)
主要な著者: Rodriguez Camargo, Diana C., Garg, Divita, Buday, Katalin, Franko, Andras, Camargo, Andres Rodriguez, Schmidt, Fabian, Cox, Sarah, Suladze, Saba, Haslbeck, Martin, Mideksa, Yonatan G., Gemmecker, Gerd, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Walch, Axel Karl, de Angelis, Martin Hrabě, Feige, Matthias, Sierra, Cesar A., Conrad, Marcus, Tripsianes, Konstantinos, Ramamoorthy, Ayyalusamy, Reif, Bernd
フォーマット: Artigo
言語:Inglês
出版事項: 2018
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5970100/
https://ncbi.nlm.nih.gov/pubmed/29745410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc03097a
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