Diabetes Drug Discovery: hIAPP(1–37) Polymorphic Amyloid Structures as Novel Therapeutic Targets

Human islet amyloid peptide (hIAPP(1–37)) aggregation is an early step in Diabetes Mellitus. We aimed to evaluate a family of pharmaco-chaperones to act as modulators that provide dynamic interventions and the multi-target capacity (native state, cytotoxic oligomers, protofilaments and fibrils of hI...

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Veröffentlicht in:Molecules
Hauptverfasser: Fernández-Gómez, Isaac, Sablón-Carrazana, Marquiza, Bencomo-Martínez, Alberto, Domínguez, Guadalupe, Lara-Martínez, Reyna, Altamirano-Bustamante, Nelly F., Jiménez-García, Luis Felipe, Pasten-Hidalgo, Karina, Castillo-Rodríguez, Rosa Angélica, Altamirano, Perla, Marrero, Suchitil Rivera, Revilla-Monsalve, Cristina, Valdés-Sosa, Peter, Salamanca-Gómez, Fabio, Garrido-Magaña, Eulalia, Rodríguez-Tanty, Chryslaine, Altamirano-Bustamante, Myriam M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017868/
https://ncbi.nlm.nih.gov/pubmed/29562662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23030686
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