Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes

BACKGROUND AND AIMS: This is the first time that obesity and diabetes mellitus (DM) as protein conformational diseases (PCD) are reported in children and they are typically diagnosed too late, when β-cell damage is evident. Here we wanted to investigate the level of naturally-ocurring or real (not s...

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Publicado no:PLoS One
Main Authors: Altamirano-Bustamante, Nelly F., Garrido-Magaña, Eulalia, Morán, Eugenia, Calderón, Aurora, Pasten-Hidalgo, Karina, Castillo-Rodríguez, Rosa Angélica, Rojas, Gerardo, Lara-Martínez, Reyna, Leyva-García, Edgar, Larralde-Laborde, Mateo, Domíguez, Guadalupe, Murata, Chiharu, Margarita-Vazquez, Yolanda, Payro, Rafael, Barbosa, Manuel, Valderrama, Alejandro, Montesinos, Hortencia, Domínguez-Camacho, Alejandra, García-Olmos, Víctor H., Ferrer, Regina, Medina-Bravo, Patricia G., Santoscoy, Fernanda, Revilla-Monsalve, Cristina, Jiménez-García, Luis Felipe, Morán, Julio, Villalobos-Alva, Jalil, Villalobos, Mario Javier, Calzada-León, Raúl, Altamirano, Perla, Altamirano-Bustamante, Myriam M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446879/
https://ncbi.nlm.nih.gov/pubmed/32833960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237667
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