Unpacking the aggregation-oligomerization-fibrillization process of naturally-occurring hIAPP amyloid oligomers isolated directly from sera of children with obesity or diabetes mellitus

The formation of amyloid oligomers and fibrils of the human islet amyloid polypeptide (hIAPP) has been linked with β- cell failure and death which causes the onset, progression, and comorbidities of diabetes. We begin to unpack the aggregation-oligomerization-fibrillization process of these oligomer...

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Publicado en:Sci Rep
Main Authors: Altamirano-Bustamante, Myriam M., Altamirano-Bustamante, Nelly F., Larralde-Laborde, Mateo, Lara-Martínez, Reyna, Leyva-García, Edgar, Garrido-Magaña, Eulalia, Rojas, Gerardo, Jiménez-García, Luis Felipe, Revilla-Monsalve, Cristina, Altamirano, Perla, Calzada-León, Raúl
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895187/
https://ncbi.nlm.nih.gov/pubmed/31804529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54570-8
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