Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for t...

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Detaylı Bibliyografya
Yayımlandı:Genome Med
Asıl Yazarlar: Stein-O’Brien, Genevieve, Kagohara, Luciane T., Li, Sijia, Thakar, Manjusha, Ranaweera, Ruchira, Ozawa, Hiroyuki, Cheng, Haixia, Considine, Michael, Schmitz, Sandra, Favorov, Alexander V., Danilova, Ludmila V., Califano, Joseph A., Izumchenko, Evgeny, Gaykalova, Daria A., Chung, Christine H., Fertig, Elana J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2018
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966898/
https://ncbi.nlm.nih.gov/pubmed/29792227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0545-2
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