Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer

Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to define cancer-specific SEs and their role in carcinogenesis. In this work, we develop a simple pipeline, which can...

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Publicat a:Sci Rep
Autors principals: Flam, Emily L., Danilova, Ludmila, Kelley, Dylan Z., Stavrovskaya, Elena, Guo, Theresa, Considine, Michael, Qian, Jiang, Califano, Joseph A., Favorov, Alexander, Fertig, Elana J., Gaykalova, Daria A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803762/
https://ncbi.nlm.nih.gov/pubmed/31636280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51018-x
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