CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways in previously untreated tumors. Therefore, this study uses bioinformatics algori...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Fertig, Elana J., Ozawa, Hiroyuki, Thakar, Manjusha, Howard, Jason D., Kagohara, Luciane T., Krigsfeld, Gabriel, Ranaweera, Ruchira S., Hughes, Robert M., Perez, Jimena, Jones, Siân, Favorov, Alexander V., Carey, Jacob, Stein-O'Brien, Genevieve, Gaykalova, Daria A., Ochs, Michael F., Chung, Christine H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342018/
https://ncbi.nlm.nih.gov/pubmed/27650546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12075
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