CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways in previously untreated tumors. Therefore, this study uses bioinformatics algori...

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Vydáno v:Oncotarget
Hlavní autoři: Fertig, Elana J., Ozawa, Hiroyuki, Thakar, Manjusha, Howard, Jason D., Kagohara, Luciane T., Krigsfeld, Gabriel, Ranaweera, Ruchira S., Hughes, Robert M., Perez, Jimena, Jones, Siân, Favorov, Alexander V., Carey, Jacob, Stein-O'Brien, Genevieve, Gaykalova, Daria A., Ochs, Michael F., Chung, Christine H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342018/
https://ncbi.nlm.nih.gov/pubmed/27650546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12075
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