Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for t...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Stein-O’Brien, Genevieve, Kagohara, Luciane T., Li, Sijia, Thakar, Manjusha, Ranaweera, Ruchira, Ozawa, Hiroyuki, Cheng, Haixia, Considine, Michael, Schmitz, Sandra, Favorov, Alexander V., Danilova, Ludmila V., Califano, Joseph A., Izumchenko, Evgeny, Gaykalova, Daria A., Chung, Christine H., Fertig, Elana J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966898/
https://ncbi.nlm.nih.gov/pubmed/29792227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0545-2
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