Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

BACKGROUND: Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genome Med
Hauptverfasser: Stein-O’Brien, Genevieve, Kagohara, Luciane T., Li, Sijia, Thakar, Manjusha, Ranaweera, Ruchira, Ozawa, Hiroyuki, Cheng, Haixia, Considine, Michael, Schmitz, Sandra, Favorov, Alexander V., Danilova, Ludmila V., Califano, Joseph A., Izumchenko, Evgeny, Gaykalova, Daria A., Chung, Christine H., Fertig, Elana J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966898/
https://ncbi.nlm.nih.gov/pubmed/29792227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0545-2
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge