CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways in previously untreated tumors. Therefore, this study uses bioinformatics algori...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Fertig, Elana J., Ozawa, Hiroyuki, Thakar, Manjusha, Howard, Jason D., Kagohara, Luciane T., Krigsfeld, Gabriel, Ranaweera, Ruchira S., Hughes, Robert M., Perez, Jimena, Jones, Siân, Favorov, Alexander V., Carey, Jacob, Stein-O'Brien, Genevieve, Gaykalova, Daria A., Ochs, Michael F., Chung, Christine H.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342018/
https://ncbi.nlm.nih.gov/pubmed/27650546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12075
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki