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BindProfX: Assessing Mutation-Induced Binding Affinity Change by Protein Interface Profiles with Pseudo-Counts

Understanding how gene-level mutations affect the binding affinity of protein–protein interactions is a key issue of protein engineering. Due to the complexity of the problem, using physical force field to predict the mutation-induced binding free-energy change remains challenging. In this work, we...

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Vydáno v:J Mol Biol
Hlavní autoři: Xiong, Peng, Zhang, Chengxin, Zheng, Wei, Zhang, Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963940/
https://ncbi.nlm.nih.gov/pubmed/27899282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.11.022
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