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iSEE: Interface structure, evolution, and energy‐based machine learning predictor of binding affinity changes upon mutations

Quantitative evaluation of binding affinity changes upon mutations is crucial for protein engineering and drug design. Machine learning‐based methods are gaining increasing momentum in this field. Due to the limited number of experimental data, using a small number of sensitive predictive features i...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Geng, Cunliang, Vangone, Anna, Folkers, Gert E., Xue, Li C., Bonvin, Alexandre M. J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587874/
https://ncbi.nlm.nih.gov/pubmed/30417935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25630
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