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Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles.

The formation of protein-protein complexes is essential for proteins to perform their physiological functions in the cell. Mutations that prevent the proper formation of the correct complexes can have serious consequences for the associated cellular processes. Since experimental determination of pro...

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Detalhes bibliográficos
Main Authors: Jeffrey R Brender, Yang Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2015-10-01
Colecção:PLoS Computational Biology
Acesso em linha:http://europepmc.org/articles/PMC4624718?pdf=render
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