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BindProfX: Assessing Mutation-Induced Binding Affinity Change by Protein Interface Profiles with Pseudo-Counts
Understanding how gene-level mutations affect the binding affinity of protein–protein interactions is a key issue of protein engineering. Due to the complexity of the problem, using physical force field to predict the mutation-induced binding free-energy change remains challenging. In this work, we...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5963940/ https://ncbi.nlm.nih.gov/pubmed/27899282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.11.022 |
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