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SSIPe: accurately estimating protein–protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function
MOTIVATION: Most proteins perform their biological functions through interactions with other proteins in cells. Amino acid mutations, especially those occurring at protein interfaces, can change the stability of protein–protein interactions (PPIs) and impact their functions, which may cause various...
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| Veröffentlicht in: | Bioinformatics |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7178439/ https://ncbi.nlm.nih.gov/pubmed/31830252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz926 |
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