Deep learning techniques have significantly impacted protein structure prediction and protein design

af Pearce, Robin, Zhang, Yang
Udgivet i Curr Opin Struct Biol (2021)

Toward the solution of the protein structure prediction problem

af Pearce, Robin, Zhang, Yang
Udgivet i J Biol Chem (2021)

EvoEF2: accurate and fast energy function for computational protein design

af Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang
Udgivet i Bioinformatics (2020)

FASPR: an open-source tool for fast and accurate protein side-chain packing

af Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang
Udgivet i Bioinformatics (2020)

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

af Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang
Udgivet i Aging (Albany NY) (2020)

Toward the Accuracy and Speed of Protein Side-Chain Packing: A Systematic Study on Rotamer Libraries

af Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang
Udgivet i J Chem Inf Model (2019)

EvoDesign: Designing protein-protein binding interactions using evolutionary interface profiles in conjunction with an optimized physical energy function

af Pearce, Robin, Huang, Xiaoqiang, Setiawan, Dani, Zhang, Yang
Udgivet i J Mol Biol (2019)

SSIPe: accurately estimating protein–protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function

af Huang, Xiaoqiang, Zheng, Wei, Pearce, Robin, Zhang, Yang
Udgivet i Bioinformatics (2020)

Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment

af Huang, Xiaoqiang, Pearce, Robin, Omenn, Gilbert S., Zhang, Yang
Udgivet i Int J Mol Sci (2021)

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering

af Ong, Edison, Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang, He, Yongqun
Udgivet i bioRxiv (2020)

Identifying zoonotic origin of SARS-CoV-2 by modeling the binding affinity between Spike receptor-binding domain and host ACE2

af Huang, Xiaoqiang, Zhang, Chengxin, Pearce, Robin, Omenn, Gilbert S., Zhang, Yang
Udgivet i bioRxiv (2020)

Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity Between the Spike Receptor-Binding Domain and Host ACE2

af Huang, Xiaoqiang, Zhang, Chengxin, Pearce, Robin, Omenn, Gilbert S., Zhang, Yang
Udgivet i J Proteome Res (2020)

Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering

af Ong, Edison, Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang, He, Yongqun
Udgivet i Comput Struct Biotechnol J (2020)

A new protocol for atomic-level protein structure modeling and refinement using low-to-medium resolution cryo-EM density maps

af Zhang, Biao, Zhang, Xi, Pearce, Robin, Shen, Hong-Bin, Zhang, Yang
Udgivet i J Mol Biol (2020)

The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K(m)) Catalyst

af Pearce, Robin E., Cohen-Wolkowiez, Michael, Sampson, Mario R., Kearns, Gregory L.
Udgivet 2013

In Vitro Hepatic Oxidative Biotransformation of Trimethoprim

af Goldman, Jennifer L., Leeder, J. Steven, Van Haandel, Leon, Pearce, Robin E.
Udgivet i Drug Metab Dispos (2015)

LOMETS2: improved meta-threading server for fold-recognition and structure-based function annotation for distant-homology proteins

af Zheng, Wei, Zhang, Chengxin, Wuyun, Qiqige, Pearce, Robin, Li, Yang, Zhang, Yang
Udgivet i Nucleic Acids Res (2019)

Deep-learning contact-map guided protein structure prediction in CASP13

af Zheng, Wei, Li, Yang, Zhang, Chengxin, Pearce, Robin, Mortuza, S. M., Zhang, Yang
Udgivet i Proteins (2019)

FUpred: detecting protein domains through deep-learning-based contact map prediction

af Zheng, Wei, Zhou, Xiaogen, Wuyun, Qiqige, Pearce, Robin, Li, Yang, Zhang, Yang
Udgivet i Bioinformatics (2020)

Evaluation of a [(13)C]-Dextromethorphan Breath Test to Assess CYP2D6 Phenotype

af Leeder, J. Steven, Pearce, Robin E., Gaedigk, Andrea, Modak, Anil, Rosen, David I.
Udgivet i J Clin Pharmacol (2008)