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Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles

The formation of protein-protein complexes is essential for proteins to perform their physiological functions in the cell. Mutations that prevent the proper formation of the correct complexes can have serious consequences for the associated cellular processes. Since experimental determination of pro...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Brender, Jeffrey R., Zhang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624718/
https://ncbi.nlm.nih.gov/pubmed/26506533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004494
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