Transient and Local Expression of Chemokine and Immune Checkpoint Traps To Treat Pancreatic Cancer

Pancreatic tumors are known to be resistant to immunotherapy due to the extensive immune suppressive tumor microenvironment (TME). We hypothesized that CXCL12 and PD-L1 are two key molecules controlling the immunosuppressive TME. Fusion proteins, called traps, designed to bind with these two molecul...

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Detaylı Bibliyografya
Yayımlandı:ACS Nano
Asıl Yazarlar: Miao, Lei, Li, Jingjing, Liu, Qi, Feng, Richard, Das, Manisit, Lin, C. Michael, Goodwin, Tyler J., Dorosheva, Oleksandra, Liu, Rihe, Huang, Leaf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961942/
https://ncbi.nlm.nih.gov/pubmed/28809532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01786
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