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Transient and Local Expression of Chemokine and Immune Checkpoint Traps To Treat Pancreatic Cancer
Pancreatic tumors are known to be resistant to immunotherapy due to the extensive immune suppressive tumor microenvironment (TME). We hypothesized that CXCL12 and PD-L1 are two key molecules controlling the immunosuppressive TME. Fusion proteins, called traps, designed to bind with these two molecul...
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| Veröffentlicht in: | ACS Nano |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5961942/ https://ncbi.nlm.nih.gov/pubmed/28809532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01786 |
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