Transient and Local Expression of Chemokine and Immune Checkpoint Traps To Treat Pancreatic Cancer

Pancreatic tumors are known to be resistant to immunotherapy due to the extensive immune suppressive tumor microenvironment (TME). We hypothesized that CXCL12 and PD-L1 are two key molecules controlling the immunosuppressive TME. Fusion proteins, called traps, designed to bind with these two molecul...

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Pubblicato in:ACS Nano
Autori principali: Miao, Lei, Li, Jingjing, Liu, Qi, Feng, Richard, Das, Manisit, Lin, C. Michael, Goodwin, Tyler J., Dorosheva, Oleksandra, Liu, Rihe, Huang, Leaf
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961942/
https://ncbi.nlm.nih.gov/pubmed/28809532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01786
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