Transient and Local Expression of Chemokine and Immune Checkpoint Traps To Treat Pancreatic Cancer

Pancreatic tumors are known to be resistant to immunotherapy due to the extensive immune suppressive tumor microenvironment (TME). We hypothesized that CXCL12 and PD-L1 are two key molecules controlling the immunosuppressive TME. Fusion proteins, called traps, designed to bind with these two molecul...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Miao, Lei, Li, Jingjing, Liu, Qi, Feng, Richard, Das, Manisit, Lin, C. Michael, Goodwin, Tyler J., Dorosheva, Oleksandra, Liu, Rihe, Huang, Leaf
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961942/
https://ncbi.nlm.nih.gov/pubmed/28809532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01786
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