Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth

The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown. Pancreatic cancer poses crucial challenges for immune therapeutic interventions due to low mutational-burden and consequent lack of neoantige...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Oncol
Prif Awduron: Das, Manisit, Zhou, Xuefei, Liu, Yun, Das, Anirban, Vincent, Benjamin G., Li, Jingjing, Liu, Rihe, Huang, Leaf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Neoplasia Press 2020
Pynciau:
Original article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7475277/
https://ncbi.nlm.nih.gov/pubmed/32862105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100856
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