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Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

BACKGROUND: Integrase strand transfer inhibitors (INSTIs) are the class of antiretroviral (ARV) drugs most recently approved by the FDA for the treatment of HIV-1 infections. INSTIs block the strand transfer reaction catalyzed by HIV-1 integrase (IN) and have been shown to potently inhibit infection...

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Podrobná bibliografie
Vydáno v:Retrovirology
Hlavní autoři: Smith, Steven J., Zhao, Xue Zhi, Burke, Terrence R., Hughes, Stephen H.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956922/
https://ncbi.nlm.nih.gov/pubmed/29769116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0420-7
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