HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

[Image: see text] HIV integrase (IN) strand transfer inhibitors (INSTIs) are among the newest anti-AIDS drugs; however, mutant forms of IN can confer resistance. We developed noncytotoxic naphthyridine-containing INSTIs that retain low nanomolar IC(50) values against HIV-1 variants harboring all of...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Zhao, Xue Zhi, Smith, Steven J., Maskell, Daniel P., Metifiot, Mathieu, Pye, Valerie E., Fesen, Katherine, Marchand, Christophe, Pommier, Yves, Cherepanov, Peter, Hughes, Stephen H., Burke, Terrence R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2016
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836387/
https://ncbi.nlm.nih.gov/pubmed/26808478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00948
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller