HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

[Image: see text] HIV integrase (IN) strand transfer inhibitors (INSTIs) are among the newest anti-AIDS drugs; however, mutant forms of IN can confer resistance. We developed noncytotoxic naphthyridine-containing INSTIs that retain low nanomolar IC(50) values against HIV-1 variants harboring all of...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Zhao, Xue Zhi, Smith, Steven J., Maskell, Daniel P., Metifiot, Mathieu, Pye, Valerie E., Fesen, Katherine, Marchand, Christophe, Pommier, Yves, Cherepanov, Peter, Hughes, Stephen H., Burke, Terrence R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836387/
https://ncbi.nlm.nih.gov/pubmed/26808478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00948
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