Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. These small molecules bind to the IN active site, causing it to disengage from the deoxyadenosine at the 3′ end of viral DNA. The emer...

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Detaylı Bibliyografya
Asıl Yazarlar: Hare, Stephen, Smith, Steven J., Métifiot, Mathieu, Jaxa-Chamiec, Albert, Pommier, Yves, Hughes, Stephen H., Cherepanov, Peter
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2011
Konular:
Accelerated Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187526/
https://ncbi.nlm.nih.gov/pubmed/21719464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.073189
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