Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. These small molecules bind to the IN active site, causing it to disengage from the deoxyadenosine at the 3′ end of viral DNA. The emer...

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Main Authors: Hare, Stephen, Smith, Steven J., Métifiot, Mathieu, Jaxa-Chamiec, Albert, Pommier, Yves, Hughes, Stephen H., Cherepanov, Peter
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Accelerated Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187526/
https://ncbi.nlm.nih.gov/pubmed/21719464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.073189
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