Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

[Image: see text] Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG). The second-generation agent, dolutegravir (DTG), has enjoyed considerable clinical success; however, resist...

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Publicat a:J Med Chem
Autors principals: Zhao, Xue Zhi, Smith, Steven J., Maskell, Daniel P., Métifiot, Mathieu, Pye, Valerie E., Fesen, Katherine, Marchand, Christophe, Pommier, Yves, Cherepanov, Peter, Hughes, Stephen H., Burke, Terrence R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601359/
https://ncbi.nlm.nih.gov/pubmed/28737946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00596
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