Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

[Image: see text] Integrase mutations can reduce the effectiveness of the first-generation FDA-approved integrase strand transfer inhibitors (INSTIs), raltegravir (RAL) and elvitegravir (EVG). The second-generation agent, dolutegravir (DTG), has enjoyed considerable clinical success; however, resist...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zhao, Xue Zhi, Smith, Steven J., Maskell, Daniel P., Métifiot, Mathieu, Pye, Valerie E., Fesen, Katherine, Marchand, Christophe, Pommier, Yves, Cherepanov, Peter, Hughes, Stephen H., Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601359/
https://ncbi.nlm.nih.gov/pubmed/28737946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00596
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados