Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)

The majority of HIV-1 integrase amino acid sites are highly conserved, suggesting that most are necessary to carry out the critical structural and functional roles of integrase. We analyzed the 34 most variable sites in integrase (>10% variability) and showed that prevalent polymorphic amino acid...

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Detalhes bibliográficos
Main Authors: Vavro, Cindy, Hasan, Samiul, Madsen, Heather, Horton, Joseph, DeAnda, Felix, Martin-Carpenter, Louise, Sato, Akihiko, Cuffe, Robert, Chen, Shuguang, Underwood, Mark, Nichols, Garrett
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591886/
https://ncbi.nlm.nih.gov/pubmed/23295935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01791-12
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