Bicyclic 1-Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV-1 Integrase Inhibitors Having High Antiviral Potency against Cells Harboring Raltegravir-Resistant Integrase Mutants

[Image: see text] Integrase (IN) inhibitors are the newest class of antiretroviral agents developed for the treatment of HIV-1 infections. Merck’s Raltegravir (RAL) (October 2007) and Gilead’s Elvitegravir (EVG) (August 2012), which act as IN strand transfer inhibitors (INSTIs), were the first anti-...

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Detalhes bibliográficos
Main Authors: Zhao, Xue Zhi, Smith, Steven J., Métifiot, Mathieu, Johnson, Barry C., Marchand, Christophe, Pommier, Yves, Hughes, Stephen H., Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983366/
https://ncbi.nlm.nih.gov/pubmed/24471816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401902n
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