HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants

[Image: see text] Integrase strand transfer inhibitors (INSTIs) block the integration step of the retroviral lifecycle and are first-line drugs used for the treatment of HIV-1/AIDS. INSTIs have a polycyclic core with heteroatom triads, chelate the metal ions at the active site, and have a halobenzyl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ACS Infect Dis
Main Authors: Smith, Steven J., Zhao, Xue Zhi, Passos, Dario Oliveira, Pye, Valerie E., Cherepanov, Peter, Lyumkis, Dmitry, Burke, Terrence R., Hughes, Stephen H.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205226/
https://ncbi.nlm.nih.gov/pubmed/33686850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00819
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker