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HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants

Integrase strand transfer inhibitors (INSTIs) have emerged as clinically effective therapeutics that inhibit HIV-1 replication by blocking the strand transfer reaction catalyzed by HIV-1 integrase (IN). Of the three FDA-approved INSTIs, dolutegravir (DTG) is the least apt to select for resistance. H...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Smith, Steven J., Zhao, Xue Zhi, Burke, Terrence R., Hughes, Stephen H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125528/
https://ncbi.nlm.nih.gov/pubmed/29987149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01035-18
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