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HIV-1 Integrase Inhibitors That Are Broadly Effective against Drug-Resistant Mutants
Integrase strand transfer inhibitors (INSTIs) have emerged as clinically effective therapeutics that inhibit HIV-1 replication by blocking the strand transfer reaction catalyzed by HIV-1 integrase (IN). Of the three FDA-approved INSTIs, dolutegravir (DTG) is the least apt to select for resistance. H...
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| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6125528/ https://ncbi.nlm.nih.gov/pubmed/29987149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01035-18 |
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