A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

The selectivity of an enzyme inhibitor is a key determinant of its usefulness as a tool compound or its safety as a drug. Yet selectivity is never assessed comprehensively in the early stages of the drug discovery process, and only rarely even in the later stages, because technical limitations prohi...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Bachovchin, Daniel A., Koblan, Luke W., Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H., Poplawski, Sarah E., Kiritsy, Christopher P., Healey, Sarah E., DiMare, Matthew, Sanford, David G., Munford, Robert S., Bachovchin, William W., Golub, Todd R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953424/
https://ncbi.nlm.nih.gov/pubmed/24997602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1578
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