Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle–regulated exocytosis in mast cells

Mast cells (MCs) play pivotal roles in many inflammatory conditions including infections, anaphylaxis, and asthma. MCs store immunoregulatory compounds in their large cytoplasmic granules and, upon stimulation, secrete them via regulated exocytosis. Exocytosis in many cells requires the participatio...

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Vydáno v:J Biol Chem
Hlavní autoři: Gutierrez, Berenice A., Chavez, Miguel A., Rodarte, Alejandro I., Ramos, Marco A., Dominguez, Andrea, Petrova, Youlia, Davalos, Alfredo J., Costa, Renan M., Elizondo, Ramon, Tuvim, Michael J., Dickey, Burton F., Burns, Alan R., Heidelberger, Ruth, Adachi, Roberto
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950006/
https://ncbi.nlm.nih.gov/pubmed/29599294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002455
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