Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle–regulated exocytosis in mast cells

Mast cells (MCs) play pivotal roles in many inflammatory conditions including infections, anaphylaxis, and asthma. MCs store immunoregulatory compounds in their large cytoplasmic granules and, upon stimulation, secrete them via regulated exocytosis. Exocytosis in many cells requires the participatio...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gutierrez, Berenice A., Chavez, Miguel A., Rodarte, Alejandro I., Ramos, Marco A., Dominguez, Andrea, Petrova, Youlia, Davalos, Alfredo J., Costa, Renan M., Elizondo, Ramon, Tuvim, Michael J., Dickey, Burton F., Burns, Alan R., Heidelberger, Ruth, Adachi, Roberto
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950006/
https://ncbi.nlm.nih.gov/pubmed/29599294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002455
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