Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis

Platelet degranulation, a form of regulated exocytosis, is crucial for hemostasis and thrombosis. Exocytosis in platelets is mediated by SNARE proteins, and in most mammalian cells this process is controlled by Munc18 (mammalian homolog of Caenorhabditis elegans uncoordinated gene 18) proteins. Plat...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Cardenas, Eduardo I., Gonzalez, Ricardo, Breaux, Keegan, Da, Qi, Gutierrez, Berenice A., Ramos, Marco A., Cardenas, Rodolfo A., Burns, Alan R., Rumbaut, Rolando E., Adachi, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442067/
https://ncbi.nlm.nih.gov/pubmed/30696774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006922
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