Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained

The proprotein convertase subtilisin/kexin type-9 (PCSK9) plays a central role in cardiovascular disease (CVD) by degrading hepatic low-density lipoprotein receptor (LDLR). As such, loss-of-function (LOF) PCSK9 variants that fail to exit the endoplasmic reticulum (ER) increase hepatic LDLR levels an...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Lebeau, Paul, Platko, Khrystyna, Al-Hashimi, Ali A., Byun, Jae Hyun, Lhoták, Šárka, Holzapfel, Nicholas, Gyulay, Gabriel, Igdoura, Suleiman A., Cool, David R., Trigatti, Bernardo, Seidah, Nabil G., Austin, Richard C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5950004/
https://ncbi.nlm.nih.gov/pubmed/29593095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001049
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