Endoplasmic Reticulum Stress and Ca(2+) Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism

Accumulating evidence implicates endoplasmic reticulum (ER) stress as a mediator of impaired lipid metabolism, thereby contributing to fatty liver disease and atherosclerosis. Previous studies demonstrated that ER stress can activate the sterol regulatory element-binding protein-2 (SREBP2), an ER-lo...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Lebeau, Paul, Al-Hashimi, Ali, Sood, Sudesh, Lhoták, Šárka, Yu, Pei, Gyulay, Gabriel, Paré, Guillaume, Chen, S. R. Wayne, Trigatti, Bernardo, Prat, Annik, Seidah, Nabil G., Austin, Richard C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270491/
https://ncbi.nlm.nih.gov/pubmed/27909053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.744235
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