SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation

Activation-induced deaminase (AID) initiates hypermutation of Ig genes in activated B cells by converting C:G into U:G base pairs. G(1)-phase variants of uracil base excision repair (BER) and mismatch repair (MMR) then deploy translesion polymerases including REV1 and Pol η, which exacerbates mutati...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Thientosapol, Eddy Sanchai, Bosnjak, Daniel, Durack, Timothy, Stevanovski, Igor, van Geldermalsen, Michelle, Holst, Jeff, Jahan, Zeenat, Shepard, Caitlin, Weninger, Wolfgang, Kim, Baek, Brink, Robert, Jolly, Christopher J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948975/
https://ncbi.nlm.nih.gov/pubmed/29669924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719771115
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