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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
Somatic hypermutation of Ig genes enables B cells of the germinal center to generate high-affinity immunoglobulin variants. Key intermediates in somatic hypermutation are deoxyuridine lesions, introduced by activation-induced cytidine deaminase. These lesions can be processed further to abasic sites...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118202/ https://ncbi.nlm.nih.gov/pubmed/16476771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052227 |
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