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Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice
Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymera...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660925/ https://ncbi.nlm.nih.gov/pubmed/19008189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2008.0223 |
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