Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigen(K164R) mutant mice

Proliferating cell nuclear antigen (PCNA) encircles DNA as a ring-shaped homotrimer and, by tethering DNA polymerases to their template, PCNA serves as a critical replication factor. In contrast to high-fidelity DNA polymerases, the activation of low-fidelity translesion synthesis (TLS) DNA polymera...

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Main Authors: Langerak, Petra, Krijger, Peter H.L., Heideman, Marinus R., van den Berk, Paul C.M., Jacobs, Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660925/
https://ncbi.nlm.nih.gov/pubmed/19008189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2008.0223
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