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The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination
To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C tra...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012132/ https://ncbi.nlm.nih.gov/pubmed/21209924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015236 |
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