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A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNA(K164) modification
B cells use translesion DNA synthesis (TLS) to introduce somatic mutations around genetic lesions caused by activation-induced cytidine deaminase. Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS. To determine the role of PCNA(K164) modifications in...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118671/ https://ncbi.nlm.nih.gov/pubmed/17664295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070902 |
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